:::Mutation spectra of RAS gene family in colorectal cancer.
Mutation spectra of RAS gene family in colorectal cancer. 員工報告
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| 計畫摘要 | Background The clinicopathologic features and frequency of KRAS mutations in colorectal cancer (CRC) patients have been reported； however, the characteristics and impact of NRAS and HRAS mutations on the survival of CRC patients have seldom been addressed. Methods Under institutional review board approval, 1,519 CRC patients who underwent surgery were enrolled. Mutation status of RAS was determined by polymerase chain reaction and mass spectrophotometry. Results The frequency of KRAS, NRAS, and HRAS mutations was 39.6%, 4.3%, and 1.7%, respectively. The KRAS mutation was associated with fewer left-sided tumors, fewer poor differentiated tumors, more mucin component, and less lymphovascular invasion. The NRAS or HRAS mutations were not associated with any of the clinicopathologic features examined. After univariate analysis, only NRAS mutation was associated with patients' overall and disease-free survival. However, the association of NRAS with patients' overall and disease-free survival disappeared after stepwise elimination. Conclusions This study demonstrates the clinicopathologic characteristics of CRC patients with RAS mutations. Patients with NRAS mutation tended to have worse outcomes. |
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| 資料集研究(主辦)機關 | 衛生局聯合醫院 |
| 年度 | 105 |
| 研究人員 | Chang YY, Lin PC(林佩菁), Lin HH, Lin JK, Chen WS, Jiang JK, Yang SH, Liang WY, Chang SC. |
| 關鍵詞 | 期刊 |
| 備註 | 本專區110年以前為歷史轉檔資料，因新舊平臺欄位規格不同，故有部分詮釋資料欄位無資訊；如對資料內容有疑義，請洽資料集主辦機關或本府研考會研究發展組。 |