:::Common and unique mechanisms of Chinese herbal remedies on ischemic stroke mice revealed by transcriptome analyses.
Common and unique mechanisms of Chinese herbal remedies on ischemic stroke mice revealed by transcriptome analyses. 員工報告
| 資料項目 | 檔案大小 | 檔案格式 | 更新時間 | 操作 |
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| 計畫摘要 | "ETHNOPHARMACOLOGICAL RELEVANCE: Four traditional Chinese herbal remedies (CHR) including Buyang Huanwu decoction (BHD), Xuefu Zhuyu decoction (XZD), Tianma Gouteng decoction (TGD) and Shengyu decoction (SYD) are popular used in treating brain-related dysfunction clinically with different syndrome/pattern based on traditional Chinese medicine (TCM) principles, yet their neuroprotective mechanisms are still unclear. MATERIALS AND METHODS: Mice were subjected to an acute ischemic stroke to examine the efficacy and molecular mechanisms of action underlying these CHR. RESULTS: CHR treatment significantly enhanced the survival rate of stroke mice, with BHD being the most effective CHR. All CHR were superior to recombinant tissue-type plasminogen activator (rt-PA) treatment in successfully ameliorating brain function, infarction, and neurological deficits in stroke mice that also paralleled to improvements in blood-brain barrier damage, inflammation, apoptosis, and neurogenesis. Transcriptome analyses reveals that a total of 774 ischemia-induced probe sets were significantly modulated by four CHR, including 52 commonly upregulated genes and 54 commonly downregulated ones. Among them, activation of neurogenesis-associated signaling pathways and down-regulating inflammation and apoptosis pathways are key common mechanisms in ischemic stroke protection by all CHR. Besides, levels of plasma CX3CL1 and S100a9 in patients could be used as biomarkers for therapeutic evaluation before functional recovery could be observed. CONCLUSION: Our results suggest that using CHR, a combinatory cocktail therapy, is a better way than rt-PA for treating cerebral ischemic-associated diseases through modulating a common as well as a specific group of genes/pathways that may partially explain the syndrome differentiation and treatment principle in TCM." |
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| 資料集研究(主辦)機關 | 衛生局聯合醫院 |
| 年度 | 104 |
| 研究人員 | Shen YC,Lu CK,Liou KT,Hou YC,Lin YL,Wang YH,Sun HJ,Liao KH,Wang HW(王學偉) |
| 關鍵詞 | 期刊 |
| 備註 | 本專區110年以前為歷史轉檔資料，因新舊平臺欄位規格不同，故有部分詮釋資料欄位無資訊；如對資料內容有疑義，請洽資料集主辦機關或本府研考會研究發展組。 |